Citizens’ media in latin america

There are several reasons that explain why community and citizens’ media are so widespread and popular in Latin America. This chapter offers a series of short vignettes set in Colombia that describe the intricate processes that developed there since the 1920s and simultaneously elsewhere across Latin America, spreading the notion that agency and participation are everyone’s right. These vignettes highlight why understanding community and citizens’ media in Latin America requires recognizing the long history of radical politics in the region and the wide dissemination of leftist ideologies that popularized notions of popular participation and political agency as rights. The chapter also brings into dialogue the work of Peruvian scholar Rosa María Alfaro, who was instrumental in transforming communication scholarship in Latin America and is an early example of citizens’ media in Latin America. Including a translation of this key early text by Alfaro was a challenge, because the field is vast and there is so much material that has never been translated into English or published outside of Latin America. In selecting the following piece, the intention is to maintain the centrality of both theory and practice and to show how citizens’ media in Latin America cannot be understood unless we take into consideration what social movements and grassroots communities did in the region and how Latin American scholars thought about the region

New acyclic diaminocarbenes cycloplatinated(II) complexes: synthesis, photophysical properties and cytotoxic activity

Among all phosphorescent molecules, cyclometalated platinum(II) complexes have receivedconsiderable attention because of their photophysical properties and potential applications asdopants in OLEDs, LECs, photocatalysts or bioimaging. Another research of relevant interest istheir employment as anticancer drugs with a broader spectrum of action against differenttumours and fewer side effects than the well-known cisplatin. For that reason, the choice of thecyclometalated group and ancillary ligands play an important role not only in emissive behaviorbut also on the biological activity.1N-acyclic diaminocarbenes (ADCs) show several appealing characteristics; they display strongelectron-donating ability with structural flexibility and can be easily prepared. However, thereare only a few examples of ADC-platinum complexes used as perspective metal-based drugs inthe literature.2In this contribution, we describe a series of new luminescent ADC cycloplatinated(II) compoundsfeaturing 2-(2,4-difluorophenyl)pyridine (3) and 2-phenylquinoline (4) cyclometalated groups[Pt(C^N)Cl{C(NHXyl)(NHR)}] (R = Pr a, Benzyl b) obtained by nucleophilic addition of primarypropyl and benzyl amines, to the isocyanide ligand of the corresponding precursors[Pt(C^N)Cl(CNXyl)] (1, 2) recently reported by our group.3 Their optical properties haveexamined and interpreted with the aid of DFT/TD-DFT calculations and, finally, all newcompounds have been screened for their cytotoxic activity against various cancer cell lines

The use of cosmic muons in detecting heterogeneities in large volumes

The muon intensity attenuation method to detect heterogeneities in large matter volumes is analyzed. Approximate analytical expressions to estimate the collection time and the signal to noise ratio, are proposed and validated by Monte Carlo simulations. Important parameters, including point spread function and coordinate reconstruction uncertainty are also estimated using Monte Carlo simulations.Comment: 8 pages, 11 figures, submetted to NIM

Asymptotics and zeros of Sobolev orthogonal polynomials on unbounded supports

In this paper we present a survey about analytic properties of polynomials orthogonal with respect to a weighted Sobolev inner product such that the vector of measures has an unbounded support. In particular, we are focused in the study of the asymptotic behaviour of such polynomials as well as in the distribution of their zeros. Some open problems as well as some new directions for a future research are formulated.Comment: Changed content; 34 pages, 41 reference

Hierarchical Star Formation: Stars and Stellar Clusters in the Gould Belt

We perform a study of the spatial and kinematical distribution of young open clusters in the solar neighborhood, discerning between bound clusters and transient stellar condensations within our sample. Then, we discriminate between Gould Belt (GB) and local Galactic disk (LGD) members, using a previous estimate of the structural parameters of both systems obtained from a sample of O-B6 Hipparcos stars. Using this classified sample we analyze the spatial structure and the kinematic behavior of the cluster system in the GB. The two star formation regions that dominate and give the GB its characteristic inclined shape show a striking difference in their content of star clusters: while Ori OB1 is richly populated by open clusters, not a single one can be found within the boundaries of Sco OB2. This is mirrored in the velocity space, translating again into an abundance of clusters in the region of the kinematic space populated by the members of Ori OB1, and a marginal number of them associated to Sco OB2. In the light of these results we study the nature of the GB with respect to the optical segment of the Orion Arm, and we propose that the different content of star clusters, the different heights over the Galactic plane and the different residual velocities of Ori OB1 and Sco OB2 can be explained in terms of their relative position to the density maximum of the Local Arm in the solar neighborhood. Although morphologically intriguing, the GB appears to be the result of our local and biased view of a larger star cluster complex in the Local Arm, that could be explained by the internal dynamics of the Galactic disk.Comment: 23 pages, including 12 figures. Accepted for publication in MNRA

Study of the Very High Energy Emission of M87 through its Broadband Spectral Energy Distribution

The radio galaxy M87 is the central dominant galaxy of the Virgo Cluster. Very high-energy (VHE, ≳0.1 TeV) emission from M87 has been detected by imaging air Cherenkov telescopes. Recently, marginal evidence for VHE long-term emission has also been observed by the High Altitude Water Cherenkov Observatory, a gamma-ray and cosmic-ray detector array located in Puebla, Mexico. The mechanism that produces VHE emission in M87 remains unclear. This emission originates in its prominent jet, which has been spatially resolved from radio to X-rays. In this paper, we construct a spectral energy distribution from radio to gamma rays that is representative of the nonflaring activity of the source, and in order to explain the observed emission, we fit it with a lepto-hadronic emission model. We found that this model is able to explain nonflaring VHE emission of M87 as well as an orphan flare reported in 2005

Test results for the V0 detector in ALICE

ALIC

Doxorubicin plus lurbinectedin in patients with advanced endometrial cancer: Results from an expanded phase i study

Objective: Second-line treatment of endometrial cancer is an unmet medical need. We conducted a phase I study evaluating lurbinectedin and doxorubicin intravenously every 3 weeks in patients with solid tumors. The aim of this study was to characterise the efficacy and safety of lurbinectedin and doxorubicin for patients with endometrial cancer. Methods: Thirty-four patients were treated: 15 patients in the escalation phase (doxorubicin 50 mg/m2 and lurbinectedin 3.0-5.0 mg) and 19 patients in the expansion cohort (doxorubicin 40 mg/m2 and lurbinectedin 2.0 mg/m2). All histological subtypes were eligible and patients had received one to two prior lines of chemotherapy for advanced disease. Antitumor activity was evaluated every two cycles according to the Response Evaluation Criteria in Solid Tumors version 1.1. Adverse events were graded according to the National Cancer Institute-Common Terminology Criteria for Adverse Events version 4. Results: Median age (range) was 65 (51-78) years. Eastern Cooperative Oncology Group performance status was up to 1 in 97% of patients. In the escalation phase, 4 (26.7%) of 15 patients had confirmed response: two complete and two partial responses (95% CI 7.8% to 55.1%). Median duration of response was 19.5 months. Median progression-free survival was 7.3 (2.5 to 10.1) months. In the expansion cohort, confirmed partial response was reported in 8 (42.1%) of 19 patients (95% CI 20.3% to 66.5%). Median duration of response was 7.5 (6.4 to not reached) months, median progression-free survival was 7.7 (2.0 to 16.7) months and median overall survival was 14.2 (4.5 to not reached) months. Fatigue (26.3% of patients), and transient and reversible myelosuppression (neutropenia, 78.9%; febrile neutropenia, 21.1%; thrombocytopenia, 15.8%) were the main grade 3 and higher toxicities in the expanded cohort. Conclusions: In patients with recurrent advanced endometrial cancer treated with doxorubicin and lurbinectedin, response rates (42%) and duration of response (7.5 months) were favorable. Further evaluation of doxorubicin and lurbinectedin is warranted in this patient population